This is the first report of nanofibrous PEC from chitosan and casein for rapid clotting, to the best of our knowledge

Antimicrobial and Wound Healing Properties of FeO Fabricated Chitosan/PVA Nanocomposite Sponge.Diabetic and anemia-related diabetic lesions increase the considerable morbidity and mortality in multitudes, as accounted by clinical studies no anemia-linked diabetic wound dressing stuffs have been arised until now this study purposed to develop a nanocomposite scaffold composed of chitosan (CS), poly (vinyl alcohol) (PVA), and phytogenic iron oxide nanoparticles (FeO NPs), for accelerated anemia-associated diabetic wound healing.  benefits of vitamin d3  extract of Pinus densiflora (PD) was utilized for the synthesis of iron oxide nanoparticles (FeO NPs). TEM and elemental analysis corroborated smaller size PD-FeO NPs (<50 nm) synthesis with the combination of iron and oxide. In addition, in vitro biological studies exposed the moderate antioxidant, antidiabetic activities, and considerable antibacterial activity of PD-FeO NPs the different concentrations of PD-FeO NPs (0, 0, and 0%) incorporated CS/PVA nanocomposites poriferans were developed by the freeze-drying method. The porous structured morphology and the presence of PD-FeO NPs were followed under FE-SEM.

Among nanocomposite poriferans, PD-FeO NPs (0%) integrated CS/PVA parasites were further chosen for the in vitro wound-healing assay, established on the porous and water sorption nature the in vitro wound-healing assay unveiled that PD-FeO NPs (0%) contained CS/PVA has significantly increased the cell proliferation in HEK293 cellphones. In conclusion, the CS/PVA-PD-FeO NPs (0%) sponge would be advocated for diabetic wound garmenting after a detailed in vivo evaluation.Intranasal galantamine/chitosan complex nanoparticles elicit neuroprotection potentialitys in rat minds via antioxidant effect.BACKGROUND: Alzheimer's disease is a common cause of dementia in the elderly. Galantamine hydrobromide (GH) is an anti-Alzheimer cholinesterase inhibitor that has an intrinsic antioxidant effect. In a previous study, GH was complexed with chitosan to prepare intranasal GH/chitosan complex nanoparticles (CX-NP2). The nanoparticles were situated in rat nousses 1 h after nasal administration and expressed pharmacological superiority to GH nasal solution without exhibiting histopathological toxicity This study purported to investigate whether the long-term administration of CX-NP2 runs to biochemical toxicity in rat brainpowers compared to GH nasal solution CX-NP2 dispersion and GH solution were administrated intranasally to male Wistar rats for 30 days (3 mg/kg/day).

Malondialdehyde (MDA), lipid peroxidation marker, glutathione (GSH), superoxide dismutase (SOD) activity and tumor necrosis factor-α (TNF-α) were valuated in the brain excerptions in all radicals There was statistically insignificant difference between the CX-NP2 and GH nasal solution addressed radicals in all biochemical toxicity arguments appraised MDA and TNF-α levels in the CX-NP2-plowed group significantly minifyed equated to the control group. Also, GSH level and SOD activity were significantly heightened in CX-NP2 treated group compared to the control group CX-NP2 did not induce a statistically significant oxidative stress or neuroinflammation in rat Einsteins after 30-day treatment, they rather elicited neuroprotective voltages.HighlightsIntranasal GH/chitosan complex nanoparticles (CX-NP2) show calling potential as a brain pointing carrier.likened to GH nasal solution, nasal CX-NP2 formulation did not exert oxidative stress nor neuroinflammation when administered for 30 days.A novel biodegradable injectable chitosan hydrogel for subduing postoperative trauma and battling multiple tumours.Wound bacterial infections and tumor recurrence are the main grounds for the poor prognosis after primary tumor resection we constructed a novel therapeutic nanocomposite utilizing chitosan (CS) hydrogel aggregated with black phosphate nanosheets (BPNSs) and in situ uprised copper nanoparticles (CuNPs). The geted hydrogel (CS@BPNSs@CuNPs), having a remarkable temperature-sensitive spongy-like state, bided 24 % blood coagulating index.